Technology

A proprietary technology guarantees a reproductible manufacturing process of calibrated magnetic emulsions. The fragmentation under controlled shearing allows for the preparation of 100 to 500 nm uniform magnetic emulsions (see figure below).

The nanoparticles are superparamagnetic : they exhibit magnetic properties only when placed within a magnetic field and show no residual magnetism when removed from this field.

 

Ademtech has developed in-house polymerisation process ensuring an efficient isolation of the magnetic core, a tuneable functionalisation and a high colloidal stability.

 

The polymer provides the magnetic core with a uniform protective shell in order to isolate iron oxides that can interfere with some enzymatic reactions (as shown on Transmission Electron Microscopy photos).

The hydrophilic surface lowers non-specific interactions with proteins.  The high magnetic content (more than 70%) ensures a quick and gentle magnetic separation even for the smallest particles with a simple magnet.


Ademtech has developed simple and reproductible protocols for coupling proteins to its nanoparticles yielding to high binding capacities while keeping non-specific binding low and ensuring long-term stability.

 

 

Self-organisation of magnetic particles occurs when stimulated by a magnetic field. Separation is gentle and no column or centrifugations are necessary. 

 

 

 

Ademtech manufactures calibrated particles (CV<20%) of 100 to 500 nm, with high magnetic content (70% of iron oxides) and controlled surface bearing various functionalities – carboxylic acids and amine – and biological activities brought by streptavidine, antibodies or proteins A and G

 

These magnetic particles are especially designed for concentration, separation, purification and identification of molecules and specific cells. Besides, they are particularly suitable for integration in microfluidic devices.

 

Ademtech offers its core expertise to customised coupling services based on the nano particules in order to develop specific purification tools.

 

For the near future, ADEMTECH is developing some diagnostic and scientific research applications offering a global solution to the costumers including devices and instruments.